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IMPACT-F: Expert system to predict oral bioavailability in humans IMPACT-F optimizes lead candidates in Drug Discovery.pdf Images and graphics are available here
Tierversuche koennen den medizinischen Fortschritt behindern.pdf PACT-F (Preclinical And Clinical Trials Knowledge Base on Bioavailability) Product launch of PACT-F Novel database PACT-F unifies the knowledge of 100 years of drug research.pdf Neue Datenbank PACT-F vereint das Wissen von 100 Jahren Forschung an Medikamenten.pdf Press Release Animal testing can mislead drug discovery and development Several blockbuster drugs would not be on the market, if scientists had relied solely on drug-uptake in animal trials, according to new research. The research, carried out by PharmaInformatic, a German biotech company, compared study results on drug-uptake (“Oral Bioavailability”) in animals and humans for a large number of approved and established drugs. Efficacy issues are identified as the main reason why clinical trials fail.
Animal testing can mislead drug discovery and development.pdf
Results showed that oral bioavailability in animals is inconsistent with the values reported for humans and large differences can exist. This also applies to very successful commercial drugs, called blockbuster drugs, with annual sales of more than one billion US Dollar.
In drug development today, a large number of compounds are tested in animals, such as rats, dogs, monkeys and mice to determine whether they are effective and possess sufficient oral bioavailability. If bioavailability in animals is too low, further drug development is usually discontinued.
Drug-uptake studies in animals can be misleading: Aripiprazole and Esomeprazole, the most sold drugs of 2013, have low oral bioavailability in animals, but drug-uptake in humans is high.
Alternative computational methods, such as the expert system IMPACT-F replace animal trials on drug-uptake.
Pharmaceutical companies have applied the expert system to evaluate human oral bioavailability in various therapeutic areas such as diabetes, inflammation, antivirals, autoimmune diseases and cancer.
The expert system evaluates oral bioavailability in humans significantly more reliably than animal trials. This further increases the prospects of human clinical trials, because the optimum oral dose for first-in-human clinical trials can be determined much more accurately.
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PACT-F: The fundamental knowledge base to analyse the factors which influence oral bioavailability
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