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PharmaInformatic was founded in 2004 and provides ADME Knowledge Bases and predictive tools (Expert Systems) to improve drug discovery and development. The company is based in Emden, Germany.

Current research results on drug-uptake (oral bioavailability) in animals and humans show:
Animal trials can mislead drug discovery and development. Top selling drugs, including the most sold blockbuster drugs of 2013, would not be on the market, if scientists had relied solely on drug-uptake in animal trials. Further details, press release.

New collaborations:
Pharmaceutical companies apply IMPACT-F to estimate oral bioavailability in humans. The expert system is used to select and prioritise drug-candidates, to optimise prodrugs and to find optimum dose for first-in-human clinical trials.
It has been used in various therapeutic areas such as diabetes, inflammation, antivirals, autoimmune diseases and cancer. IMPACT-F reduces clinical failures and increases savety and prospects of clinical trials (more).


IMPACT-F:  Prediction of oral bioavailability in humans (drug-uptake)

The expert system IMPACT-F accelerates drug discovery and development: It calculates oral bioavailability of future drugs in humans. Predictions were shown to be much more precise than animal trials: they were as accurate as the common deviation between individual humans taking part in the same clinical trial. Read our current research results on bioavailability of drugs.

Computational models such as IMPACT-F replace animal trials: they require no experimental effort and results are almost immediately available. Since they are significantly more reliable than animal models, they increase the prospects of successful clinical trials in humans.

PACT-F:  Largest knowledge base on bioavailability of drugs worldwide

PharmaInformatic has developed a comprehensive knowledge base on bioavailability, which enables the targeted development of new drugs. The development of the knowledge base began in 2005. Since then the detailed results and conditions of more than 5000 scientific publications concerning the bioavailability of drugs have been evaluated and integrated into the database (more).

PACT-F is now the largest knowledge base on bioavailability worldwide. It contains 8296 records, which describe in detail the results of clinical trials in humans and preclinical trials in animals, see content of PACT-F.

Oral bioavailability is one of the most important properties of a drug. If a new drug candidate has low or no oral bioavailability, further drug development is stopped. Low oral bioavailability in clinical trials is a major reason for drug candidates failing to reach the market. Efficacy issues have been identified as the main reason why clinical trials fail.